Narcotic drugs, which are often prescribed in IBS, might be another factor causing SIBO because they inhibit gut motility. Additionally, IBS patients may have overlapping functional dyspepsia, therefore they may consume more proton pump inhibitors, which may influence the development of SIBO. Indeed, it has been observed that, in this subset of patients, a higher bacterial load at jejunal aspirate culture was associated with looser stools. The most important ones are female gender, old age, bloating and flatulence as the main manifestations, and diarrhea-predominant IBS. There are various factors that are linked to SIBO in patients with IBS. In this regard, the most recent meta-analysis on the topic, based on 25 studies with 3192 patients with IBS and 3320 controls, showed that the prevalence in patients with IBS was significantly higher than in controls (odds ratio = 3.7) additionally, it was found that SIBO occurred more frequently in IBS-diarrhea subtype (35.5%) than in those with constipation (22.5%).įurther considerations may be assumed from the available data. Case-control studies, in which the diagnosis was achieved by a breath test, revealed that SIBO was more common among IBS than controls, suggesting a significant association. The frequency of SIBO among subjects with IBS ranged between 4% and 78%, while in healthy asymptomatic controls, only 1%–40% had SIBO. Based on this observation, several studies tried to investigate the link between IBS and SIBO. Patients with SIBO experience abdominal pain or discomfort, bloating and flatulence as well. IBS typical symptoms are abdominal pain and/or discomfort, irregular stool appearance and bowel movements or bloating.

Irritable bowel syndrome (IBS) is the most common gastrointestinal functional disorder affecting the population worldwide.

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